A-99 Influence of TBI on Rate of Cognitive Decline in Clinically Normal Older Adults

Abstract Objective History of traumatic brain injury (TBI) is a potential risk factor for cognitive decline and neurodegenerative disease later in life, but findings have been inconsistent. We evaluate if past history TBI affects rate clinically normal older adults. Method Participants were 190 cognitively (CDR < 0.5) adults (age at baseline: M = 71.6, SD 7.0) with positive (TBI+; n 83) or no (TBI-; 107). A comprehensive neuropsychological battery attention, memory, language, executive functioning measures as well functional questionnaires administered longitudinally (number visits: 3.4, 1.3). Linear mixed effects models assessed the interaction between longitudinal health outcomes history. Results TBI+ showed faster (Stroop interference: p 0.04), increase impairment (Physical Activity Scale Elderly (PASE) total: 0.001; Unified Parkinson’s Disease Rating (UPDRS) 0.002). Baseline performance on these tests did not distinguish from TBI- interference, 0.4; PASE, 0.5; UPDRS, 0.1). was significantly different other domains. Conclusions associated more rapid objective subjective Findings suggest that sustaining earlier life could accelerate changes even among